Dr Aleks Reinhardt | The Reinhardt Group

Associate Professor

In my research, I use computer simulations and statistical mechanics to study the behaviour of molecular and colloidal systems. In particular, I am interested in phase transitions, nucleation and self-assembly, and how thermodynamic and kinetic factors affect and control them.

Dr Reinhardt discusses his research

Publications

Physical determinants of multiphase organisation in multi-component protein/RNA condensates

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

Biophysical Journal

(2023)

122

295A

(doi: 10.1016/j.bpj.2022.11.1672)

Thermodynamic origins of two-component multiphase condensates of proteins.

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

Chem Sci

(2023)

14

1820

(doi: 10.1039/d2sc05873a)

Signaling by cluster formation investigated with single-molecule fluorescence in living cells

S Weyrauch, C Lan, J Kim, S Ulferts, F Aprile-Garcia, A Anandamurugan, R Grosse, R Sawarkar, A Reinhardt, T Hugel

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2023)

52

S213

Phase diagrams—why they matter and how to predict them

PY Chew, A Reinhardt

The Journal of chemical physics

(2022)

158

030902

(doi: 10.1063/5.0131028)

Simulations of DNA-Origami Self-Assembly Reveal Design-Dependent Nucleation Barriers

A Cumberworth, D Frenkel, A Reinhardt

Nano letters

(2022)

22

6916

(doi: 10.1021/acs.nanolett.2c01372)

Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation

C Lan, J Kim, S Ulferts, F Aprile-Garcia, A Anandamurugan, R Grosse, R Sawarkar, A Reinhardt, T Hugel

bioRxiv

(2022)

(doi: 10.1101/2022.08.01.502196)

Designing multiphase biomolecular condensates by coevolution of protein mixtures

PY Chew, JA Joseph, R Collepardo-Guevara, A Reinhardt

(2022)

(doi: 10.1101/2022.04.22.489187)

Same and interconvertible high-pressure ice phases

A Reinhardt, M Bethkenhagen, F Coppari, M Millot, S Hamel, B Cheng

(2022)

(doi: 10.48550/arxiv.2203.12897)

Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy

JA Joseph, A Reinhardt, A Aguirre, PY Chew, KO Russell, JR Espinosa, A Garaizar, R Collepardo-Guevara

Biophysical Journal

(2022)

121

307a

(doi: 10.1016/j.bpj.2021.11.1214)

Comparison of experimental phase diagrams and residue-level coarse-grained simulations of intrinsically disordered proteins

MJ Maristany, R Collepardo-Guevara, JA Joseph, A Reinhardt

Biophysical Journal

(2022)

121

471a

(doi: 10.1016/j.bpj.2021.11.408)